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Publications

Huang, A., Mangold-Döring, A., Guan, H., Boerwinkel, M.-C., Belgers, D., Focks, A., & Van den Brink, P. J. (2023). The effect of temperature on toxicokinetics and the chronic toxicity of insecticides towards Gammarus pulex. Science of the Total Environment, 856, 158886.

Mangold-Döring, A., Huang, A., Van Nes, E. H., Focks, A., & Van den Brink, P. J. (2022). Explicit consideration of temperature improves predictions of Toxicokinetic–Toxicodynamic models for Flupyradifurone and Imidacloprid in Gammarus pulex. Environmental science & technology, 56(22), 15920–15929.

Sousa, J. P., Aldrich, A., Axelman, J., Backhaus, T., Brendel, S., Dorronsoro, B., Duquesne, S., Focks, A., Holz, S., Knillmann, S., & others. (2022). Building a European P artnership for next generation, systems-based E nvironmental R isk A ssessment (PERA) Final Roadmap Report. EFSA Supporting Publications, 19(8), 7546E.

Huang, A., Mangold-Döring, A., Focks, A., Zhang, C., & Van den Brink, P. J. (2022). Comparing the acute and chronic toxicity of flupyradifurone and imidacloprid to non-target aquatic arthropod species. Ecotoxicology and Environmental Safety, 243, 113977.

Ayllón, D., Railsback, S. F., Gallagher, C., Augusiak, J., Baveco, H., Berger, U., Charles, S., Martin, R., Focks, A., Galic, N., Liu, C., Loon, E. E. van, Nabe-Nielsen, J., Piou, C., Polhill, J. G., Preuss, T. G., Radchuk, V., Schmolke, A., Stadnicka-Michalak, J., … Grimm, V. (2021). Keeping modelling notebooks with TRACE: Good for you and good for environmental research and management support. Environmental Modelling & Software, 136, 104932. https://doi.org/10.1016/j.envsoft.2020.104932

Arlos, M. J., Focks, A., Hollender, J., & Stamm, C. (2020). Improving Risk Assessment by Predicting the Survival of Field Gammarids Exposed to Dynamic Pesticide Mixtures. Environmental Science & Technology, 54(19), 12383–12392. https://doi.org/10.1021/acs.est.0c03939

Gils, J. van, Posthuma, L., Cousins, I. T., Brack, W., Altenburger, R., Baveco, H., Focks, A., Greskowiak, J., Kühne, R., Kutsarova, S., Lindim, C., Markus, A., Meent, D. van de, Munthe, J., Schueder, R., Schüürmann, G., Slobodnik, J., Zwart, D. de, & Wezel, A. van. (2020). Computational material flow analysis for thousands of chemicals of emerging concern in European waters. Journal of Hazardous Materials, 397, 122655. doi.org/10.1016/j.jhazmat.2020.122655

Berg, S. J. P. V. den, Rendal, C., Focks, A., Butler, E., Peeters, E. T. H. M., Laender, F. D., & Brink, P. J. V. den. (2020). Potential impact of chemical stress on freshwater invertebrates: A sensitivity assessment on continental and national scale based on distribution patterns, biological traits, and relatedness. Science of The Total Environment, 731, 139150. https://doi.org/10.1016/j.scitotenv.2020.139150

Brock, T., Arena, M., Cedergreen, N., Charles, S., Duquesne, S., Ippolito, A., Klein, M., Reed, M., Teodorovic, I., Brink, P. J., & Focks, A. (2020). Application of General Unified Threshold Models of Survival Models for Regulatory Aquatic Pesticide Risk Assessment Illustrated with an Example for the Insecticide Chlorpyrifos. Integrated Environmental Assessment and Management, 17(1), 243–258. https://doi.org/10.1002/ieam.4327

Forbes, V. E., Agatz, A., Ashauer, R., Butt, K. R., Capowiez, Y., Duquesne, S., Ernst, G., Focks, A., Gergs, A., Hodson, M. E., Holmstrup, M., Johnston, A. S., Meli, M., Nickisch, D., Pieper, S., Rakel, K. J., Reed, M., Roembke, J., Schäfer, R. B., … Roeben, V. (2020). Mechanistic Effect Modeling of Earthworms in the Context of Pesticide Risk Assessment: Synthesis of the FORESEE Workshop. Integrated Environmental Assessment and Management, 17(2), 352–363. https://doi.org/10.1002/ieam.4338

Gestel, C. A., Mommer, L., Montanarella, L., Pieper, S., Coulson, M., Toschki, A., Rutgers, M., Focks, A., & Römbke, J. (2020). Soil Biodiversity: State-of-the-Art and Possible Implementation in Chemical Risk Assessment. Integrated Environmental Assessment and Management. https://doi.org/10.1002/ieam.4371

Posthuma, L., Zijp, M. C., Zwart, D. D., Meent, D. V. de, Globevnik, L., Koprivsek, M., Focks, A., Gils, J. V., & Birk, S. (2020). Chemical pollution imposes limitations to the ecological status of European surface waters. Scientific Reports, 10(1). doi.org/10.1038/s41598-020-71537-2

Dalhoff, K., Hansen, A. M. B., Rasmussen, J. J., Focks, A., Strobel, B. W., & Cedergreen, N. (2020). Linking Morphology, Toxicokinetic, and Toxicodynamic Traits of Aquatic Invertebrates to Pyrethroid Sensitivity. Environmental Science & Technology, 54(9), 5687–5699. https://doi.org/10.1021/acs.est.0c00189

Sun, M., Duker, R. Q., Gillissen, F., Van den Brink, P. J., Focks, A., & Rico, A. (2020). Influence of pH on the toxicity of ionisable pharmaceuticals and personal care products to freshwater invertebrates. Ecotoxicology and Environmental Safety, 191.

Burdon, F. J., Munz, N. A., Reyes, M., Focks, A., Joss, A., Räsänen, K., Altermatt, F., Eggen, R. I. L., & Stamm, C. (2019). Agriculture versus wastewater pollution as drivers of macroinvertebrate community structure in streams. Science of the Total Environment, 659, 1256–1265.

Van Den Berg, S. J. P., Baveco, H., Butler, E., De Laender, F., Focks, A., Franco, A., Rendal, C., & Van Den Brink, P. J. (2019). Modeling the Sensitivity of Aquatic Macroinvertebrates to Chemicals Using Traits. Environmental Science and Technology, 53(10), 6025–6034.

Backhaus, T., Brack, W., Van den Brink, P. J., Deutschmann, B., Hollert, H., Posthuma, L., Segner, H., Seiler, T.-B., Teodorovic, I., & Focks, A. (2019). Assessing the ecological impact of chemical pollution on aquatic ecosystems requires the systematic exploration and evaluation of four lines of evidence. Environmental Sciences Europe, 31(1).

Brack, W., Ait-Aissa, S., Altenburger, R., Cousins, I., Dulio, V., Escher, B., Focks, A., Ginebreda, A., Hering, D., Hilscherová, K., Hollender, J., Hollert, H., Kortenkamp, A., de Alda, M. L., Posthuma, L., Schymanski, E., Segner, H., & Slobodnik, J. (2019). Let us empower the WFD to prevent risks of chemical pollution in European rivers and lakes. Environmental Sciences Europe, 31(1).

Brack, W., Ait-Aissa, S., Backhaus, T., Birk, S., Barceló, D., Burgess, R., Cousins, I., Dulio, V., Escher, B. I., Focks, A., van Gils, J., Ginebreda, A., Hering, D., Hewitt, L. M., Hilscherová, K., Hollender, J., Hollert, H., Köck, M., Kortenkamp, A., … Altenburger, R. (2019). Strengthen the European collaborative environmental research to meet European policy goals for achieving a sustainable, non-toxic environment. Environmental Sciences Europe, 31(1).

Altenburger, R., Brack, W., Burgess, R. M., Busch, W., Escher, B. I., Focks, A., Mark Hewitt, L., Jacobsen, B. N., de Alda, M. L., Ait-Aissa, S., Backhaus, T., Ginebreda, A., Hilscherová, K., Hollender, J., Hollert, H., Neale, P. A., Schulze, T., Schymanski, E. L., Teodorovic, I., … Krauss, M. (2019). Future water quality monitoring: Improving the balance between exposure and toxicity assessments of real-world pollutant mixtures. Environmental Sciences Europe, 31(1).

Posthuma, L., Altenburger, R., Backhaus, T., Kortenkamp, A., Müller, C., Focks, A., de Zwart, D., & Brack, W. (2019). Improved component-based methods for mixture risk assessment are key to characterize complex chemical pollution in surface waters. Environmental Sciences Europe, 31(1).

Posthuma, L., Brack, W., van Gils, J., Focks, A., Müller, C., de Zwart, D., & Birk, S. (2019). Mixtures of chemicals are important drivers of impacts on ecological status in European surface waters. Environmental Sciences Europe, 31(1).

Van den Brink, P. J., Buijert - de Gelder, D. M., Brock, T. C. M., Roessink, I., & Focks, A. (2019). Exposure pattern-specific species sensitivity distributions for the ecological risk assessments of insecticides. Ecotoxicology and Environmental Safety, 180, 252–258.

Vighi, M., Barsi, A., Focks, A., & Grisoni, F. (2019). Predictive models in ecotoxicology: Bridging the gap between scientific progress and regulatory applicability?Remarks and research needs. Integrated Environmental Assessment and Management, 15(3), 345–351.

Focks, A., Belgers, D., Boerwinkel, M.-C., Buijse, L., Roessink, I., & Brink, P. J. V. den. (2018). Calibration and validation of toxicokinetic-toxicodynamic models for three neonicotinoids and some aquatic macroinvertebrates. Ecotoxicology, 27(7), 992–1007. https://doi.org/10.1007/s10646-018-1940-6

Focks, A., Grisoni, F., Barsi, A., & Vighi, M. (2018). Predictive Models in Ecotoxicology: Bridging the Gap Between Scientific Progress and Regulatory Applicability. Integrated Environmental Assessment and Management, 14(5), 601–603.

Ginebreda, A., Sabater-Liesa, L., Rico, A., Focks, A., & Barceló, D. (2018). Reconciling monitoring and modeling: An appraisal of river monitoring networks based on a spatial autocorrelation approach—Emerging pollutants in the Danube River as a case study. Science of the Total Environment, 618, 323–335.

Roessink, I., Van Der Steen, S., Belgers, D., Baveco, H., Focks, A., & Boesten, J. (2018). Estimating honeybee forager background mortality: A case study in the Netherlands. doi.org/10.5073/JKA.2018.462.002

Ockleford, C., Adriaanse, P., Berny, P., Brock, T., Duquesne, S., Grilli, S., Hernandez-Jerez, A. F., Bennekou, S. H., Klein, M., Kuhl, T., Laskowski, R., Machera, K., Pelkonen, O., Pieper, S., Smith, R. H., Stemmer, M., Sundh, I., Tiktak, A., Topping, C. J., … Teodorovic, I. (2018). Scientific Opinion on the state of the art of Toxicokinetic/Toxicodynamic (TKTD) effect models for regulatory risk assessment of pesticides for aquatic organisms. EFSA Journal, 16(8).

Franco, A., Price, O. R., Marshall, S., Jolliet, O., Van den Brink, P. J., Rico, A., Focks, A., De Laender, F., & Ashauer, R. (2017). Toward refined environmental scenarios for ecological risk assessment of down-the-drain chemicals in freshwater environments. Integrated Environmental Assessment and Management, 13(2), 233–248.

Yakan, S. D., Focks, A., Klasmeier, J., & Okay, O. S. (2017). Numerical evaluation of bioaccumulation and depuration kinetics of PAHs in Mytilus galloprovincialis. Environmental Pollution, 220, 1244–1250. doi.org/10.1016/j.envpol.2016.11.009

Baveco, J. M., Focks, A., Belgers, D., van der Steen, J. J. M., Boesten, J. J. T. I., & Roessink, I. (2016). An energetics-based honeybee nectar-foraging model used to assess the potential for landscape-level pesticide exposure dilution. PeerJ, 2016(8).

Ashauer, R., Albert, C., Augustine, S., Cedergreen, N., Charles, S., Ducrot, V., Focks, A., Gabsi, F., Gergs, A., Goussen, B., Jager, T., Kramer, N. I., Nyman, A.-M., Poulsen, V., Reichenberger, S., Schäfer, R. B., Van Den Brink, P. J., Veltman, K., Vogel, S., … Preuss, T. G. (2016). Modelling survival: Exposure pattern, species sensitivity and uncertainty. Scientific Reports, 6.

Rico, A., Van den Brink, P. J., Gylstra, R., Focks, A., & Brock, T. C. (2016). Developing ecological scenarios for the prospective aquatic risk assessment of pesticides. Integrated Environmental Assessment and Management, 12(3), 510–521.

Rico, A., Van den Brink, P. J., Leitner, P., Graf, W., & Focks, A. (2016). Relative influence of chemical and non-chemical stressors on invertebrate communities: A case study in the Danube River. Science of the Total Environment, 571, 1370–1382.

Altenburger, R., Ait-Aissa, S., Antczak, P., Backhaus, T., Barcelo, D., Seiler, T.-B., Brion, F., Busch, W., Chipman, K., Lopez de Alda, M., de Aragao Umbuzeiro, G., Escher, B. I., Falciani, F., Faust, M., Focks, A., Hilscherova, K., Hollender, J., Hollert, H., Jaeger, F., … Brack, W. (2015). Future water quality monitoring—Adapting tools to deal with mixtures of pollutants in water resource management. Science of the Total Environment, 512, 540–551.

Diepens, N. J., Arts, G. H. P., Focks, A., & Koelmans, A. A. (2014). Uptake, Translocation, and Elimination in Sediment-Rooted Macrophytes: A Model-Supported Analysis of Whole Sediment Test Data. Environmental Science & Technology, 48(20), 12344–12353.

Focks, A., ter Horst, M., van den Berg, E., Baveco, H., & van den Brink, P. J. (2014). Integrating chemical fate and population-level effect models for pesticides at landscape scale: New options for risk assessment. Ecological Modelling, 280, 102–116.

Focks, A. (2014a). In Summary. Environmental Toxicology and Chemistry, 33(6), 1198.

Focks, A. (2014b). The challenge: Landscape ecotoxicology and spatially explicit risk assessment. Environmental toxicology and chemistry / SETAC, 33(6), 1193.

Focks, A., Luttik, R., Zorn, M., Brock, T., Roex, E., Van der Linden, T., & Van den Brink, P. J. (2014). A simulation study on effects of exposure to a combination of pesticides used in an orchard and tuber crop on the recovery time of a vulnerable aquatic invertebrate. Environmental Toxicology and Chemistry, 33(7), 1489–1498.

Grimm, V., Augusiak, J., Focks, A., Frank, B. M., Gabsi, F., Johnston, A. S. A., Liu, C., Martin, B. T., Meli, M., Radchuk, V., Thorbek, P., & Railsback, S. F. (2014). Towards better modelling and decision support: Documenting model development, testing, and analysis using TRACE. Ecological Modelling, 280, 129–139.

Jechalke, S., Focks, A., Rosendahl, I., Groeneweg, J., Siemens, J., Heuer, H., & Smalla, K. (2014). Structural and functional response of the soil bacterial community to application of manure from difloxacin-treated pigs. Fems Microbiology Ecology, 87(1), 78–88.

Meyer, A., Focks, A., Radl, V., Welzl, G., Schoening, I., & Schloter, M. (2014). Influence of Land Use Intensity on the Diversity of Ammonia Oxidizing Bacteria and Archaea in Soils from Grassland Ecosystems. Microbial Ecology, 67(1), 161–166.

Meyer, A., Focks, A., Radl, V., Keil, D., Welzl, G., Schoening, I., Boch, S., Marhan, S., Kandeler, E., & Schloter, M. (2013). Different Land Use Intensities in Grassland Ecosystems Drive Ecology of Microbial Communities Involved in Nitrogen Turnover in Soil. Plos One, 8(9).

Van den Brink, P. J., Baird, D. J., Baveco, H. (JM), & Focks, A. (2013). The use of traits-based approaches and eco(toxico)logical models to advance the ecological risk assessment framework for chemicals. Integrated Environmental Assessment and Management, 9(3), E47–E57.

Mueller, T., Rosendahl, I., Focks, A., Siemens, J., Klasmeier, J., & Matthies, M. (2013). Short-term extractability of sulfadiazine after application to soils. Environmental Pollution, 172, 180–185.

Reichel, R., Rosendahl, I., Peeters, E. T. H. M., Focks, A., Groeneweg, J., Bierl, R., Schlichting, A., Amelung, W., & Thiele-Bruhn, S. (2013). Effects of slurry from sulfadiazine- (SDZ) and difloxacin- (DIF) medicated pigs on the structural diversity of microorganisms in bulk and rhizosphere soil. Soil Biology & Biochemistry, 62, 82–91.

Richter, M. K., Focks, A., Siegfried, B., Rentsch, D., Krauss, M., Schwarzenbach, R. P., & Hollender, J. (2013). Identification and dynamic modeling of biomarkers for bacterial uptake and effect of sulfonamide antimicrobials. Environmental Pollution, 172, 208–215.

Rico, A., Geng, Y., Focks, A., & Van den Brink, P. J. (2013). Modeling environmental and human health risks of veterinary medicinal products applied in pond aquaculture. Environmental Toxicology and Chemistry, 32(5), 1196–1207.

Heuer, H., Solehati, Q., Zimmerling, U., Kleineidam, K., Schloter, M., Mueller, T., Focks, A., Thiele-Bruhn, S., & Smalla, K. (2011). Accumulation of Sulfonamide Resistance Genes in Arable Soils Due to Repeated Application of Manure Containing Sulfadiazine. Applied and Environmental Microbiology, 77(7), 2527–2530.

Zheng, C., Focks, A., Ellebrake, K., Eggers, T., & Fries, E. (2011). Sorption of ortho-Phenylphenol to Soils. Clean-Soil Air Water, 39(2), 116–120.

Focks, A., Klasmeier, J., & Matthies, M. (2010). Mechanistic link between uptake of sulfonamides and bacteriostatic effect: model development and application to experimental data from two soil microorganisms. Environmental Toxicology and Chemistry, 29(7), 1445–1452.

Schauss, K., Focks, A., Heuer, H., Kotzerke, A., Schmitt, H., Thiele-Bruhn, S., Smalla, K., Wilke, B.-M., Matthies, M., Amelung, W., Klasmeier, J., & Schloter, M. (2009). Analysis, fate and effects of the antibiotic sulfadiazine in soil ecosystems. Trac-Trends in Analytical Chemistry, 28(5), 612–618.

Schauss, K., Focks, A., Leininger, S., Kotzerke, A., Heuer, H., Thiele-Bruhn, S., Sharma, S., Wilke, B.-M., Matthies, M., Smalla, K., Munch, J. C., Amelung, W., Kaupenjohann, M., Schloter, M., & Schleper, C. (2009). Dynamics and functional relevance of ammonia-oxidizing archaea in two agricultural soils. Environmental Microbiology, 11(2), 446–456.

Heuer, H., Focks, A., Lamshoeft, M., Smalla, K., Matthies, M., & Spiteller, M. (2008). Fate of sulfadiazine administered to pigs and its quantitative effect on the dynamics of bacterial resistance genes in manure and manured soil. Soil Biology & Biochemistry, 40(7), 1892–1900.

Non-peer-reviewed

Focks, A., Lageschaar, L., Leendertse, P., Helmes, R., Bremmer, J. (2023). Environmental Indicator Crop Protection (EICP): Documentation of calculation rules. Wageningen Economic Research. doi.org/10.18174/586066

Schrenk, D., Bignami, M., Bodin, L., Chipman, J. K., del Mazo, J., Grasl‐Kraupp, B., Hogstrand, C., Hoogenboom, L. (Ron), Leblanc, J., Stefano Nebbia, C., Nielsen, E., Ntzani, E., Petersen, A., Schwerdtle, T., Vleminckx, C., Wallace, H., Focks, A., Gregorc, A., … Sand, S. (2022). Evaluation of the risks for animal health related to the presence of hydroxymethylfurfural (HMF) in feed for honey bees. EFSA Journal, 20(4). https://doi.org/10.2903/j.efsa.2022.7227

Ockleford, C., Adriaanse, P., Berny, P., Brock, T., Duquesne, S., Grilli, S., Hernandez-Jerez, A. F., Bennekou, S. H., Klein, M., Kuhl, T., Laskowski, R., Machera, K., Pelkonen, O., Pieper, S., Smith, R. H., Stemmer, M., Sundh, I., Tiktak, A., Topping, C. J., … Teodorovic, I. (2018). Scientific Opinion on the state of the art of Toxicokinetic/Toxicodynamic (TKTD) effect models for regulatory risk assessment of pesticides for aquatic organisms. EFSA Journal, 16(8).